GLPs have come so far since it was first introduced to help control diabetes. Many health benefits have been revealed from renal and neuroprotective effects, cardiovascular health, improved glycemic control, kidney protection, blood pressure and lipid improvements, sleep apnea improvements, reduced joint pain and weight management.
Here is the breakdown between GLPs and how to choose?
GLP-1 vs GLP-2 & GLP-3
GLP-1 is a single agonist also known as Ozempic and Wegovy. These are all FDA approved and available.
GLP-2 is a dual agonist also known as Mounjaro and Zepbound.
GLP-3 is a triple-agonist known as Retatrutide which is currently in phase 3 trials and expected FDA approval by summer of 2026.
Weight Loss:
GLP-1 (Single-agonist) 15% average weight loss
GLP-2 (Dual-agonists) 18-21% average weight loss
GLP-3 (Triple-agonist) 24-28% average weight loss
Specialized Health Goals:
GLP-1s effective for diabetes, kidneys, liver and heart health.
GLP-2s effective for diabetes, kidneys, liver and heart health.
GLP-3s In addition to the above, also reduced joint pain and minimized muscle loss.
Non clinical results, end-user reports reduced inflammation and water retention. Some users explain that it helped counter autoimmune issues such as Hashimotos. Others explained that it helped reduce lipodema symptoms.
Frequency of dose:
Weekly
Side effects:
GLP manufacturers report nausea, vomiting and diarrhea. GLP-3 some report a higher heart rate.
Choose the GLP which aligns with your primary goal. Most studies suggest starting on a low dosage and upping (titrating) slowly.
